EDUCATION
| Ph.D. | Biomathematics, with a emphasis in Neuroscience, University of California, Los Angeles, 1986. | |||
| B.A. | Mathematics, summa cum laude, Member of the Honors Program. Boston College, Chestnut Hill, MA., 1974. |
EXPERIENCE
| 2004- | Director, Quantitative Biology Institute, Ohio University | |||
| 1996- | Associate Professor, Neuroscience Program, Dept. Biological Sciences, Ohio University. | |||
| 1990-1996 | Assistant Professor, Neuroscience Program, Dept. Biological Sciences, Ohio University. | |||
| 1988-1990 | Staff Fellow, Mathematical Research Branch, NIH, NIDDK. | |||
| 1986-1988 | Post-doctoral Fellow (NRSA), Sponsor: W. Rall Mathematical Research Branch, NIH, NIDDK. | |||
| 1974-1978 | Computer Programmer, A. T.& T. Longlines, White Plains, N.Y. |
AWARDS AND HONORS
GRANTS
PEER REVIEWED PUBLICATIONS
Ambros-Ingerson, J., Grover, L.M., Holmes, W.R. 2008. A classification method to distinguish cell-specific responses elicited by current pulses in hippocampal CA1 pyramidal cells. Neural Comput. 20(6):1512-1536.
Colvin, R.A., Bush, A.I., Volitakis, I., Fontaine, C.P., Thomas, D., Kikuchi, K., Holmes, W.R. 2008. Insights into Zn2+ homeostasis in neurons from experimental and modeling studies. Am. J. Physiol: Cell Physiol 294:C726-C742.
Holmes, W.R. and Grover, L.M. 2006. Quantifying the magnitude of changes in synaptic level parameters with long-term potentiation. J. Neurophysiol. 96:1478-1491.
Holmes, W.R., Ambros-Ingerson, J. and Grover L.M. 2006. Fitting experimental data to models that use morphological data from public databases. J. Comput. Neurosci. 20:349-365.
Ambros-Ingerson, J. and Holmes, W.R. 2005. Analysis and comparison of morphological reconstructions of hippocampal field CA1 pyramidal cells. Hippocampus 15:302-315.
Li, Y. and Holmes, W.R. 2000. Comparison of CaMKinase II activation in a dendritic spine computed with deterministic and stochastic models of the NMDA synaptic conductance. Neurocomputing 32-33:1-7.
Holmes, W.R. 2000. Models of calmodulin trapping and CaM Kinase II activation in a dendritic spine. J. Comput. Neurosci. 8:65-85.
Aradi, I. and Holmes, W.R. 1999. Role of multiple calcium and calcium-dependent conductances in regulation of hippocampal dentate granule cell excitability. J. Comput. Neurosci. 6:215-235.
Aradi, I. and Holmes, W.R. 1999. Active dendrites regulate spatio-temporal synaptic integratoin in hippocampal dentate granule cells. Neurocomputing 26-27:45-51.
Holmes, W.R. and Aradi, I. 1998. Modeling the contributions of calcium channels and NMDA receptor channels to calcium current in dendritic spines. In: Computional Neuroscience: Trends in Research, 1998. J.M. Bower, editor. pp. 191-196.
Holmes, W.R. and Levy, W.B. 1997. Quantifying the role of inhibition in associative long-term potentiation in dentate granule cells with computational models. J. Neurophysiol. 78:103-116.
Holmes, W.R. 1996. Modeling the effects of ambient glutamate on NMDA and non-NMDA conductances, In: Computational Neuroscience. J.M. Bower, editor. Academic Press: San Diego, pp. 83-88.
Yousukhno, O.V., Holmes, W.R., and Levy, W.B. 1996. On the role of dendritic inhibition in associative LTP. In: Computational Neuroscience. J.M. Bower, editor. Academic Press: San Diego, pp. 95-100.
Holmes, W.R. 1995. Modeling the effect of glutamate diffusion and uptake on NMDA and non-NMDA receptor saturation. Biophys. J. 69(5): 1734-1747.
Holmes, W.R. and Levy, W.B. 1994. Temporal requirement for associative LTP in the dentate. Dependence on modeled Rm and Ri values. In: Computational in Neurons and Neural Systems. F. Eeckman, editor. Kluwer Press: Boston pp. 299-304.
Rall, W., Burke, R.E., Holmes, W.R., Jack, J.J.B., Redman, S.J., and Segev, I. 1992. Matching neuron model complexity to experimental data. Physiol. Rev. 72: S159-S186.
Holmes, W.R., Segev, I. and Rall, W. 1992. Interpretation of time constant and electrotonic length estimates in multi-cylinder or branched neuronal structures. J. Neurophysiol. 68: 1401-1420.
Holmes, W.R. and Rall, W. 1992. Electrotonic length estimates in neurons with dendritic tapering or somatic shunt. J. Neurophysiol. 68: 1421-1437.
Holmes, W.R. and Rall, W. 1992. Estimating the electrotonic structure of neurons with compartmental models. J. Neurophysiol. 68: 1438-1452.
Holmes, W.R. 1990. Is the function of dendritic spines to concentrate calcium? Brain Res. 519: 338-342.
Holmes, W.R. and Levy, W.B. 1990. Insights into associative long-term potentiation from computational models of NMDA receptor-mediated calcium influx and intracellular calcium concentration changes. J. Neurophysiol. 63: 1148-1168.
Holmes, W.R. and Woody, C.D. 1989. Effects of uniform and non-uniform "activation-distributions" on the cable properties of modeled cortical pyramidal neurons. Brain Res. 505: 12-22.
Holmes, W.R. 1989. The role of dendritic diameters in maximizing the effectiveness of synaptic inputs. Brain Res. 478: 127-137.
Holmes, W.R. 1986. A continuous cable method for determining the transient potential in passive dendritic trees of known morphology. Biol. Cybern. 55: 115-124.
BOOK CHAPTERS AND OTHER PUBLICATIONS
Holmes, W.R. 2005. Calcium signaling in dendritic spines. In: Modeling in the Neurosciences. G.N. Reeke, et al. (eds) CRC Press: Boca Raton, pp. 25-60.
Holmes, W.R. and Rall, W. 2003. Dendritic spines. In: The Handbook of Brain Theory and Neural Networks. Second edition. M.A. Arbib, editor. MIT Press pp. 332-335.
Holmes, W.R. and Rall, W. 1995. Dendritic spines. In: The Handbook of Brain Theory and Neural Networks. M.A. Arbib, editor. MIT Press pp. 289-292.
Commentary to Chapter 7 of The Theoretical Foundation of Dendritic Function: Classical Papers of Wilfrid Rall, MIT Press: Boston, 1994, pp. 249-252.
Holmes, W.R. 1992. Computer simulations of individual neurons. In: Methods in Neurosciences, vol. 10, Computers and Computations in the Neurosciences. P. M. Conn, editor. Academic Press: San Diego, pp. 503-525.
Holmes, W.R. and Rall, W. 1992. Electrotonic models of neuronal dendrites and single neuron computation. In: Single Neuron Computation, T. McKenna, J. Davis, and S.F. Zornetzer, eds, Academic Press: Boston, pp. 7-25.
Holmes, W.R. and Woody, C.D. 1987. The effectiveness of individual synaptic inputs with uniform and non-uniform patterns of background synaptic activity. In: Cellular Mechanisms of Conditioning and Behavioral Plasticity, C.D. Woody et al., eds, Plenum: New York, pp. 245-252.
CNS MEETING INTRODUCTION ABSTRACTS
Holmes, W.R., Jung, R., Roberts, P.A. 2008. Computational Neuroscience (CNS*2008). BMC Neuroscience 9(Suppl 1): I1.
Holmes, W.R., Jung, R., Skinner, F.K. 2007. Computational Neuroscience (CNS*2007). BMC Neuroscience 8(Suppl 2): I1.
Holmes, W.R. 2007. Computational Neuroscience: Trends in Research 2007 (CNS*2006) Neurocomputing 70 (10-12):1595-1596.
ABSTRACTS (since 2000)
Ambros-Ingerson, J., Grover, L.M., and Holmes, W.R. 2008. The upstroke of the action potential has two events that suggest initiation occurs at the nodes of Ranvier in hippocampal CA1 pyramidal cells. Program No. (in press). 2008 Abstract Viewer/Itinerary Planner. Washington DC; Society for Neuroscience.
Grover, L.M., Holmes, W.R. 2008. Mechanisms contributing to the progressive suppression of GABA inhibition during burst stimulation patterns that induce LTP. Program No. (in press). 2008 Abstract Viewer/Itinerary Planner. Washington DC; Society for Neuroscience.
Kim, E., Grover, L.M., Holmes, W.R. 2008. Decreased afferent excitability during 100 Hz high frequency stimulation in area CA1 of rat hippocampus: Consequences for long-term potentiation. Program No. (in press). 2008 Abstract Viewer/Itinerary Planner. Washington DC; Society for Neuroscience.
Ambros-Ingerson, J.,Rowe, M.H., Peterson, E.H., Holmes, W.R. 2008. Signal processing in posterior-canal bouton vestibular primary afferents. BMC Neuroscience 9(Suppl 1): P59.
Ambros-Ingerson, J., Grover, L.M., and Holmes, W.R. 2007. Current pulses elicit cell specific responses in hippocampal CA1 pyramidal cells. Program No. 476.13. 2007 Abstract Viewer/Itinerary Planner. San Diego, CA; Society for Neuroscience.
Grover, L.M., Kim, E., Holmes, W.R. 2007. Efficient LTP induction in hippocampal area CA1 over a wide range of burst intervals, with a peak near delta frequency. Program No. 582.16. 2007 Abstract Viewer/Itinerary Planner. San Diego, CA; Society for Neuroscience.
Colvin, R.A., Bush, A.I., Volitakis, I., Fontaine, C.P., Thomas, D., Kikuchi, K., Holmes, W.R. 2007. Insights into Zn2+ homeostasis in neurons and the cellular actions of clioquinol from experimental and modeling studies. Program No. 593.16. 2007 Abstract Viewer/Itinerary Planner. San Diego, CA; Society for Neuroscience.
Ambros-Ingerson, J., Grover, L.M., and Holmes, W.R. 2007. Comparison of match functions applied to records with trains of action potentials. BMC Neuroscience 8(Suppl 2): P117.
Holmes, W.R and Grover, L.M., 2006. Quantifying the magnitude of changes in synaptic level parameters with LTP. Program No. 39.13. 2006 Abstract Viewer/Itinerary Planner. Atlanta, GA; Society for Neuroscience.
Ambros-Ingerson, J., Grover, L.M., and Holmes, W.R. 2006. Sensitivity parameter analysis by evolutionary search method in a hippocampal CA1 pyramidal cell model. Program No. 101.14. 2006 Abstract Viewer/Itinerary Planner. Atlanta, GA; Society for Neuroscience.
Holmes, W.R. and Grover L.M. 2006. The mechanism of LTP affects dendritic computation. CNS*2006. Edinburgh, UK
Holmes, W.R. and Grover L.M. 2005 Fitting experimental data to models that use morphological data from public databases. CNS*2005. Madison, WI.
Ambros-Ingerson, J., Grover, L.M., and Holmes, W.R. 2005. A parameter search method for optimal matching of impulse firing waveforms from CA1 hippocampal cells. Program No.738.4. 2005 Abstract Viewer/Itinerary Planner. Washington, DC; Society for Neuroscience.
Ambros-Ingerson, J. and Holmes, W.R. 2004. Contribution of hyperpolarization-actiated (Ih) currents to the resting conductance and resting potential of hippocampal CA1 pyramidal cells Program No. 52.7. 2004 Abstract Viewer/Itinerary Planner. Washington, DC; Society for Neuroscience.
Holmes, W.R. and Zeng, S. 2004. The role of calcium signal time course on CaMKII switching behavior explored in a stochastic model of CaMKII activation in a dendritic spine. Program No. 498.2. 2004 Abstract Viewer/Itinerary Planner. Washington, DC; Society for Neuroscience.
Holmes, W.R. and Zeng, S. 2004. Stochastic model of calcium initiated reactions in a dendritic spine. CNS*04 Abstr.
Holmes, W.R., Ambros-Ingerson, J. and Grover, L.M. 2003. Modeling the magnitude of the change with LTP at individual CA1 synapses. Program No. 476.18. 2003 Abstract Viewer/Itinerary Planner. Washington, DC; Society for Neuroscience.
Ambros-Ingerson, J. and Holmes, W.R. 2003. Suitability of CA1 morphological reconstructions for computer simulations. Program No. 476.18. 2003 Abstract Viewer/Itinerary Planner. Washington, DC; Society for Neuroscience.
Holmes, W.R. and Grover, L.M. 2002. Quantifying the change at individual synapses after LTP induction in CA1. 2002 Abstracts Viewer/Itinerary Planner. Program No. 152.16. Washington DC: Society for Neuroscience. CD-ROM.
Li, Y. and Holmes, W.R. 2002. Modeling postsynaptic calmodulin stores and the effect of local calcium domains on CaMKII activation during LTP induction. 2002 Abstracts Viewer/Itinerary Planner. Program No. 150.20. Washington DC: Society for Neuroscience. CD-ROM.
Colvin, R.A., Holmes, W.R., Hammar, K. and Smith P.J.S. 2002. Analysis of extracellular proton gradients near the surface of rat cortical neurons in primary culture using the self-referencing ion selective electrode. 2002 Abstracts Viewer/Itinerary Planner. Program No. 297.19. Washington DC: Society for Neuroscience. CD-ROM.
Holmes, W.R. and Li, Y. 2001. Modeling CaMKinase II activation in dendritic spines of different shape during LTP induction. 2001 Abstracts Viewer/Itinerary Planner. Program No. 610.17. Washington DC: Society for Neuroscience. CD-ROM.
Li, Y. and Holmes, W.R. 2000. CaMKinase II activation is significantly affected by spine head shape and PSD size in LTP induction. Soc. Neurosci. Abstr. 26:1903.
SERVICE--GRANT PANELS
SERVICE--MEETINGS