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Research Summary:
Current
research interests include cancer gene therapy and nucleic acid vaccination,
gene expression vector design and development, mammalian gene expression and
transfer, ribozyme and antisense rna, gene cloning and gene function
identification, transgenic animal disease models.
Selected References:
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Sturtz, F., Waddell, K., Shulok, J., Chen, X., Caruso, M., Sanson, M., Platika, D., and
Snodgrass, R. Parameters influencing the Efficiency of the Thymidine Kinase/Ganciclovir
(TK/GCV) System in Human Glioblastoma Cell Lines. Stereotactic Funct. Neurosurg. (In
press).
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Sturtz, F., Li, Y., Shulok, J., and Chen, X. A Nonviral Cytoplasmic T7 Autogene System and
Its Applications in DNA Vaccination. In DNA Vaccines: Methods and Protocols in the Series
of Methods in Molecular Medicine, (In press), 1998.
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Chen, X., Li, Y., Xiong, K., Xie, Y., Aizicovici, S., Wagner, T.,
and Platika, D. Cancer Gene
Therapy By Direct Injection Of A Nonviral T7 Cytoplasmic Expression Vector Encoding A
Thymidine Kinase Gene. Human Gene Therapy, 9:729-736, 1998.
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Kopchick, J., Chen, X., Li, Y., Steger, R., Yun, J., Wagner, T.,
and Bartke, A. Differential In
Vivo Activities of Bovine Growth Hormone Analogs. Transgenic Research, 7:61-71, 1998.
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Xie, Y., Chen, X., and Wagner, T. E. A Novel Ribozyme Mediated, Gene "Knockdown"
Strategy For The Identification of Gene Function in Zebrafish.
Proc Natl. Acad. Sci. USA. 94:13777-13781, 1997.
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