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Research Summary:
Innate
immune responses to Group B streptococcus, a bacterial pathogen in neonates,
are studied. Research is directed
to determine which bacterial and host signals stimulate release of immune
cytokines (IL-1, IL-6, tumor necrosis factor-alpha, IL-8, IL-12, gamma
interferon) and nitric oxide which mediate natural immunity.
Cytokine regulation of inflammatory cell function is examined as a
potential immunotherapy for infectious disease.
Selected References:
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Yoder, B.J. and Goodrum, K.J. 2001. Plasmodium chabaudi chabaudi: B-1 cell
expansion correlates with semiresistance in BALB/cJ mice. Experimental
Parasitology 98:71-82.
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Grijalva,
M.J., Goodrum, K.J., and Rowland, E. (1999). Immunological characterization of
antigens released by Trypanosoma cruzi infected cells.
Journal of Parasitology. 85(4):663-671.
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Colucci,
R.A. and K.J. Goodrum (1998) Lack of interleukin-5 production by T-lymphocytes
isolated from fibromyalgia patients and normal controls after being cultured
with 1,1'-ethylidenebis tryptophan, a suspected causal contaminant of
eosinophilia-myalgia syndrome. J. Musculoskeletal Pain 6(2):19-33.
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Derrico,
C.A. and K.J. Goodrum (1996) Interleukin-12 and tumor necrosis factor-alpha
mediate innate production of gamma interferon by Group
streptococcus treated splenocytes of severe combined immunodeficiency
mice. Infect. Immun.
64:1314-1320.
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Goodrum,
K.J., J. Dierksheide and B.J. Yoder (1995) Tumor necrosis factor- acts as an
autocrine second signal with interferon-gamma to induce nitric oxide in Group
streptococcus-treated macrophages.
Infect. Immun. 63:3715-3717.
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Goodrum,
K.J., L.L. McCormick and B. Schneider (1994) Group
streptococcal-induced nitric oxide production in murine macrophages is
CR3 (CD11b/CS18) dependent. Infect.
Immun. 62:3102-3107.
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